Today’s Morning Report is presented by Dr. Oiyemhonlan!
Analgesia and Sedation
Induction = Sedation = No Analgesia (exception Ketamine)
Paralytics (Muscle Relaxant): Blocks the transmission of the action potential at the neuromuscular junction causing paralysis. Does not provide Analgesia or Sedation; patients are still aware of pain even after full conduction block. Act post-synaptically
- Non-depolarizing vs Depolarizing
- Non- depolarizing – Competitively blocks the binding of Ach to its receptors; may also directly block ionotropic activity of Ach receptors
- Depolarizing – Depolarizes the plasma membrane of the skeletal muscle fibers. This persistent depolarization makes the muscle fiber resistant to further stimulation by Ach
Board Review Question – Only Absolute Contraindication to Succinylcholine – Myasthenia Gravis (autoantibodies to the post-synaptic membrane)—prolonged paralysis; non-depolarizing agents much more harmful
Pediatric patients ( <8 yrs) due to possible muscular dystrophy and risk of hyperkalemic arrest
Overall Goal
- Relieve patient anxiety and keep them comfortable
- In the “ICU Book” the common denominator anxiety and delirium is the absence of well-being
- Reduce anxiety and
- Why reduce the anxiety of a ventilated patient?
- Prevent breath stacking – Auto peep
- Prevent pulling of lines
- Prevent vital sign derangements – Tachycardia
- Provide humane treatment
- Reduce possibility of delirium
Analgesia
Fentanyl – synthetic potent opioid analgesic; mu receptor agonist
Sedation
Benzodiazepines – increases delirium
Dexmedetomidine (Precedex) – reducing norepi release from the locus ceruleus
Sedation Scales – Useful for assessing ventilated patients arousability
Richmond Agitation Sedation Scale (RASS) (+4-(-) 5) 10 point scale
Riker Sedation – Agitation Scale (SAS) 7-1 – Dangerous Agitation – Unarousable
Ramsey Scale – (1-6) Anxious – No response
Jay Khadpe MD
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