Morning Report: 12/3/2013

Hope everyone had a happy Thanksgiving holiday weekend! Dr. Adal is back today with Morning Report!

 

Priapism

 

Definition

A persistent erection of the penis or clitoris that is not associated with sexual stimulation or desire.

 

Epidemiology

Incidence of 0.73 per 100,000 men each yr. Has a bimodal distribution of incidence, between 5-10 in children, and 20-50 in adults. More common in Sickle Cell population, with up to 45% of patients experiencing priapism at some point throughout their life.

 

Anatomy

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Pathophysiology

The precise mechanism of priapism is unknown. Persistent obstruction of venous outflow vs excess arterial inflow

 

Ishemic/Low flow priapism:  

Characterized by little or no cavernous blood flow and abnormal cavernous blood gases (hypoxic, hypercarbic, and acidotic).

The corpora cavernosa are rigid and tender to palpation.

Patients typically report pain.

 

Non-ischemic/High flow priapism:

Caused by unregulated cavernous arterial inflow.

Cavernous blood gases are not hypoxic or acidotic.

Typically the penis is neither fully rigid nor painful.

Antecedent trauma is the most commonly described etiology.

Nonischemic priapism does not require emergent treatment.

 

Stuttering/Intermittent:

Recurrent form of ischemic priapism

Repeated episodes of painful erections with intervening periods of detumescence.

Common in sickle cell patients and can lead to true ischemic priapism

 

Eitiology

Hematologic (sickle cell anemia, leukemia, thalassemia, multiple myeloma, thrombotic thrombocytopenic purpura)
Neurologic (spinal shock)
Tumors (metastatic cancers)
Perineal, pelvic or penile trauma
Iatrogenic (intracavernous injections)
Drugs (anticoagulants, anti-hypertensives, anti-depressants, PDE5 inhibitors, intracavernous injections, alpha-blockers, cocaine)
Infection (malaria, spider toxins)
Metabolic disorders (gout, hemodialysis, high lipid content, total parenteral nutrition, diabetes, amyloidosis)

 

Diagnosis

H&P, Blood Gas, Duplex ultrasound

 

Ischemic:

Corpora fully rigid, pain, no evidence of trauma

Blood gas will have dark color. Ph < 7.25, pO2 <or= 40, pCO2 >or=60

Doppler ultrasound will reveal little or no flow

 

Non-ischemic:

Corpora aren’t fully rigid, absence of pain, might have evidence of pelvic trauma

Blood gas not as dark. Ph >7.25, pO2 <or= 60, pCO2 >or=40

Doppler ultrasound will reveal normal or high flow, might reveal vascular abnormalities

 

Consider other lab tests: CBC, retic, tox screen, Hgb electrophoresis

 

Management Algorithm

Ischemic

1. Aspiration with or without irrigation (normal saline). Success rate about 30%. Enter corpora at 10 or 2 pm, to avoid the dorsal nerve arteries, vein and urethra

2. Phenylephrine injection [100 -500mcg/ml] 58% successful if done alone, 77% if followed by step 1. Patients should be on a cardiac monitor

3.  Surgical shunting

 

Non-ischemic

1. Observation vs close follow up with Urology

2. Arteriography or embolization

3. Surgical ligation

The views expressed on this blog are the author's own and do not reflect the views of their employer. Please read our full disclaimer here. Any references to clinical cases refer to patients treated at a virtual hospital, Janus General Hospital.
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Jay Khadpe MD

Editor in Chief of "The Original Kings of County" Assistant Professor of Emergency Medicine Assistant Residency Director SUNY Downstate / Kings County Hospital

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